Cyclosporin Production By Submerged Fermentation Method
Production Cost Report | Healthcare
Details: Germany - based plant Q1 2024 | From $ USD
This report entails the detailed cost evaluation of cyclosporin production by the submerged fermentation method. Submerged fermentation is a method wherein a microorganism is treated with liquid nutrient media (including soluble sugars, liquid media, molasses, etc.) that allows aerobic growth of the microbe in the presence of oxygen. The process is carried out while controlling different critical factors, such as the pH level, viscosity, temperature, foam formation, dissolved oxygen level substrate utilization, etc, in a bioreactor. In this reaction, Tolypocladium inflatum, a fungus, is fermented by the submerged fermentation method in an oxygen-filled bioreactor, resulting in the production of cyclosporin, especially cyclosporin A, as a final product.
Top Producers of Cyclosporin
- Abbvie Inc.
- Sun Pharmaceutical Industries Ltd.
- Teva Pharmaceutical Industries Ltd.
- Novartis AG
- Santen Pharmaceutical Co., Ltd.
Feedstocks for Cyclosporin
Cyclosporin is produced using a variety of fungi, specifically Tolypocladium inflatum, and a nutrient-rich media made up of some soluble sugars, molasses, and organic fluids with vegetable/fruit juice, etc., that serves as a primary feedstock for the fermentation process. Various factors can impact the procurement of its feedstock on a large scale. Factors including seasonal availability from upstream industries, production rate and production cost, and supply chain stability have a major impact on the demand and, eventually, on the market price of cyclosporin in the chemical and pharmaceutical market. The fluctuations in the price play a vital role in determining the procurement of feedstocks used as well as cyclosporin in the global market.
The project economic analysis provided in the report discusses a Germany-based plant:
- Manufacturing Process
- Process Flow
- Material Flow
- Material Balance
- Raw Material and Product's Specifications
- Raw Material Consumption
- Product and Co-Product Generation
- Capital Investment
- Land and Site Cost
- Offsites/Civil Works
- Equipment Cost
- Auxiliary Equipment Cost
- Contingency
- Engineering and Consulting Charges
- Working Capital
- Variable Cost
- Raw Material
- Utilities
- Fixed Cost
- Labor Requirement & Wages
- Overhead Expenses
- Maintenance Charges
- Financing Costs
- Interest on Working Capital
- Interest on Loans
- Depreciation Charges
- General Sales and Admin Costs
- Production Cost Summary
Report Content
Key Process Information
Evaluation of significant technical parameters along with process descriptions such as:
- Consumption of Raw Material
- Product Creation
- Block Flow Diagram
- Description of the Manufacturing Facility
Utilities Consumption
Evaluation of utilities consumed during the entire process based on:
- Consumption per unit of product generated
- Utility cost split and share of each utility in the total cost
Process Flow Diagram
Representation of various operations involved including:
- Step-wise process
- Utility consumption in each operation
Capital Cost Analysis
In-depth analysis of costs involved in setting up a new manufacturing unit, including:
- Cost of Building a Process Unit
- Cost of Setting Up the Infrastructure
- Working Capital
- Commissioning & Start-Up of the Plant
Implementation Schedule
Time frame of the project design, which includes:
- Plant Start-Up
- Plant Construction
- Engineering Fundamentals
- Raw Material Procurement
Construction Cost Details
Detailed analysis of costs involved in the operation of various functional units in the process unit and infrastructure.
Operating Cost Analysis
Evaluation of costs associated with the production of the final product, namely:
- Procurement of Raw Materials
- Consumption of Utilities
- Fixed Costs
- Depreciation
Economic Analysis
Analysis of the way in which process economics are impacted by plant capacity.
- Construction Cost
- Working Capital
- Fixed and Variable Operating Costs
- Corporate Overhead
- Depreciation
Customized Analyses
Detailed cost estimates of any industrial plant depending on your requirements, including plant capacity and location as per the need.
Compare & Choose the Right Report Version for You
You can easily get a quote for any Procurement Resource report. Just click here and raise a request. We will get back to you within 24 hours. Alternatively, you can also drop us an email at sales@procurementresource.com.