Ampicillin Production Cost Breakup from penicillin

This report proffers the thorough economics of Ampicillin production from penicillin. The first step in manufacturing Ampicillin involves producing 6-Amino Penicillanic Acid (6-APA) from Penicillin G or Penicillin V. This is achieved using either an enzymatic or chemical process, with the enzymatic method being commonly employed industrially. In the enzymatic process, immobilized enzymes are utilized to deacylate the penicillin molecule. The reaction can occur in different types of reactors, such as a fixed bed reactor or a continuously stirred tank reactor (CSTR), depending on the production requirements.

The raw materials used are typically the potassium salts of Penicillin G or Penicillin V. Once the enzymatic reaction is completed, the resulting product is filtered and the 6-APA is crystallized. These crystals are then washed with suitable solvents to purify them, followed by drying and packing for further use in the synthesis of Ampicillin.

The project economic analysis provided in the report discusses a Germany-based plant:

• Manufacturing Process
  • Process Flow
  • Material Flow
  • Material Balance
• Raw Material and Product's Specifications
  • Raw Material Consumption
  • Product and Co-Product Generation
  • Capital Investment
• Land and Site Cost
  • Offsites/Civil Works
  • Equipment Cost
  • Auxiliary Equipment Cost
  • Contingency
  • Engineering and Consulting Charges
  • Working Capital
• Variable Cost
  • Raw Material
  • Utilities
• Fixed Cost
  • Labor Requirement & Wages
  • Overhead Expenses
  • Maintenance Charges
• Financing Costs
  • Interest on Working Capital
  • Interest on Loans
• Depreciation Charges
• General Sales and Admin Costs
• Production Cost Summary