Aspartame Production By Fermentation Method

This report provides an extensive cost evaluation of aspartame production by fermentation method. The preparation of aspartame is initiated by using Brevibacterium flavum and Corynebacterium glutamicum. The bacterial strains, i.e., B. flavum and C. glutamicum, in the presence of nutrients such as molasses, carbon sources like acetic acid, and nitrogen sources like ammonia, lead to the fermentation of amino acid and help in the formation of L-aspartic acid and L-phenylalanine, as products in the fermentation tank.

The products are then segregated, purified, crystallized, and dried for aspartame production. The amino acids thus formed, are then modified to enable only certain groups to react while shielding the other parts of amino acids, and then pumped into a reactor for further reaction. The product formed by the reaction between the modified compounds, i.e., phenylaniline and aspartic acid, is then remodified by reacting it with acetic acid. It is then purified and recrystallized to yield aspartame as the final product.

Top Producers for Aspartame

• Taj Pharmaceuticals Limited
• Foodchem International Corporation
• Global Calcium Pvt., Ltd. 
• Ajinimoto Co., Inc.
• Anant Pharmaceuticals

Feedstocks for Aspartame

Aspartame is an organic compound with a sweet taste. The compound is prepared by using phenylaniline and aspartic acid as its primary feedstocks. The procurement of aspartame and its feedstocks is impacted by several factors.

Some of the primary factors, such as the cost of production, market prices, availability of its raw materials (including molasses, glucose, ammonia, and more), logistics and trading activities, etc, altogether play a vital role in governing its procurement. Moreover, factors such as its demand in the downstream pharmaceutical, chemical, food, and beverages sectors largely influence its overall procurement in the global chemical market.

The project economic analysis provided in the report discusses a Germany-based plant:

• Manufacturing Process
  • Process Flow
  • Material Flow
  • Material Balance
• Raw Material and Product's Specifications
  • Raw Material Consumption
  • Product and Co-Product Generation
  • Capital Investment
• Land and Site Cost
  • Offsites/Civil Works
  • Equipment Cost
  • Auxiliary Equipment Cost
  • Contingency
  • Engineering and Consulting Charges
  • Working Capital
• Variable Cost
  • Raw Material
  • Utilities
• Fixed Cost
  • Labor Requirement & Wages
  • Overhead Expenses
  • Maintenance Charges
• Financing Costs
  • Interest on Working Capital
  • Interest on Loans
• Depreciation Charges
• General Sales and Admin Costs
• Production Cost Summary