Last Updated: 14-June-2026
This study analyzes Captopril Production By Acylation Reaction, covering manufacturing, process flow, operating expenses, and financial considerations.
This report proffers the thorough economics of captopril production by acylation reaction. The preparation of captopril is processed by the chemical reaction between I-proline and 3-acetylthio-2-methylpropionic acid chloride. Initially, proline or I-proline is derived from glutamate using enzymes Δ1-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR). It is then reacted with 3-acetylthio-2-methylpropionic acid chloride (obtained from 3-acetylthio-2-methylpropionic acid). The reaction leads to the acylation of I-proline and leads to the formation of captopril as the final product.
Captopril is an angiotensin-converting enzyme inhibitor that is used as a medication. It is prepared by using I-proline and 3-acetylthio-2-methylpropionic acid chloride as its primary feedstock. The procurement of captopril is majorly dependent upon some factors, including the availability of its raw materials (such as glutamate for I-proline and 3-acetylthio-2-methylpropionic acid for 3-acetylthio-2-methylpropionic acid chloride), along with the logistics and distribution operations. Moreover, prominent aspects such as the demand observed for captopril in the pharmaceutical and medical industries, stability in the supply chain, variations in the production cost and market prices, as well as the governmental and economic policies altogether govern its procurement across various regions.
The project economic analysis provided in the report discusses a Germany-based plant:
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