Coumarin Production by the Perkin Reaction

This report provides an extensive cost evaluation of coumarin production by the Perkin reaction. The preparation of coumarin begins with the chemical reaction between an aromatic aldehyde and an acidic anhydride. Here, in this reaction, salicylaldehyde reacts with acetic anhydride in the presence of a base catalyst such as sodium acetate, which leads to the production of coumarin as the final product.

Top Producers of Coumarin

• Atlas Fine Chemicals 
• Omkar Speciality
• Yingyang Flavors & Fragrance
• N.S.Chemicals
• China Tuhsu

Feedstocks for Coumarin

Coumarin is synthesized using salicylaldehyde and acetic anhydride as its major feedstocks. The procurement of these feedstocks is influenced by various factors, including the availability of raw materials from upstream industries. These upstream industries include chemical manufacturing, where salicylaldehyde is typically produced from benzaldehyde derived from benzene—a basic petrochemical from the oil refining industry, and acetic anhydride is produced via the reaction of acetic acid with acetate derivatives or from acetaldehyde. The petrochemical industry plays a vital role by supplying basic chemicals like benzene and acetaldehyde. Additionally, the agricultural industry may also contribute in some synthetic pathways where natural plant sources are converted into chemical precursors. Labor costs, production rates, the cost of feedstocks, the stability of the supply chain, logistics and trade efficiency, and political and governmental regulations also significantly impact the large-scale procurement of these feedstocks. These factors collectively influence the availability and cost of coumarin in the global market, ensuring a steady flow of production.

The project economic analysis provided in the report discusses a Germany-based plant:

• Manufacturing Process
  • Process Flow
  • Material Flow
  • Material Balance
• Raw Material and Product's Specifications
  • Raw Material Consumption
  • Product and Co-Product Generation
  • Capital Investment
• Land and Site Cost
  • Offsites/Civil Works
  • Equipment Cost
  • Auxiliary Equipment Cost
  • Contingency
  • Engineering and Consulting Charges
  • Working Capital
• Variable Cost
  • Raw Material
  • Utilities
• Fixed Cost
  • Labor Requirement & Wages
  • Overhead Expenses
  • Maintenance Charges
• Financing Costs
  • Interest on Working Capital
  • Interest on Loans
• Depreciation Charges
• General Sales and Admin Costs
• Production Cost Summary