Dipyridamole Production From 5-Niroorotic Acid

This report entails the detailed cost evaluation of dipyridamole production from 5-nirrorotic acid. The preparation process is initiated by nitrating 2,4-dihydroxy-6-methylpyrimidine, which yields 5-nitroaromatic acid. The reaction is processed by reducing 5-nitroorotic acid, resulting in 5-aminoorotic acid, which is then reacted with urea or potassium cyanide to give 2,4,6,8-tetrahydroxypyrimido[5,4-d] pyrimidine, as a product.

It is then reacted with a mixture of phosphorous oxychloride and phosphorous pentachloride that leads to the formation of 2,4,6,8- tetra-chloropyrimido[5,4-d] pyrimidine as an intermediate. The intermediate is then treated with piperidine, yielding 2,6-dichloropyrimido-4,8-dipiperidino[5,4-d] pyrimidine as a resultant compound, which again reacts with diethanolamine to produce dipyridamole as the final product.

Top Producers of Dipyridamole

• Glenmark Pharma
• Dr. Reddy's Lab
• AnazaoHealth Corporation
• Pro Doc Limitee
• Hikma Pharmaceuticals

Feedstock for Dipyridamole

Dipyridamole is an antiplatelet medication produced from 5-nitroaromatic acid as its primary feedstock. The procurement of dipyridamole is influenced by various factors, including the production cost and processing of its raw materials (including urea, acetoacetic ether, etc., for 2,4-dihydroxy-6-methylpyrimidine, which is then used to yield 5-nitroaromatic acid), its supply chain stability, as well as the logistics and trading activities, etc.

Moreover, other prominent factors such as the demand observed for dipyridamole as an antiplatelet drug in healthcare and pharmaceutical industries, the variations in its market prices, transportation and distribution operations, demand from various countries (including North America, Europe, Latin America, etc.), and governmental policies strongly govern its procurement.

The project economic analysis provided in the report discusses a Germany-based plant:

• Manufacturing Process
  • Process Flow
  • Material Flow
  • Material Balance
• Raw Material and Product's Specifications
  • Raw Material Consumption
  • Product and Co-Product Generation
  • Capital Investment
• Land and Site Cost
  • Offsites/Civil Works
  • Equipment Cost
  • Auxiliary Equipment Cost
  • Contingency
  • Engineering and Consulting Charges
  • Working Capital
• Variable Cost
  • Raw Material
  • Utilities
• Fixed Cost
  • Labor Requirement & Wages
  • Overhead Expenses
  • Maintenance Charges
• Financing Costs
  • Interest on Working Capital
  • Interest on Loans
• Depreciation Charges
• General Sales and Admin Costs
• Production Cost Summary