This study analyzes Guanfacine Production From 2,6-dichlorophenylacetonitrile (I), covering manufacturing, process flow, operating expenses, and financial considerations.
Last Updated: January, 2025
This report provides an extensive cost evaluation of Guanfacine production via 2,6-dichlorophenylacetonitrile. The production process is initiated by 2,6-dichlorophenylacetonitrile, which is reacted with sulfuric acid and methanol, forming an intermediate 2,6-dichlorophenylacetate. This intermediate is then condensed with guanidine in isopropanol to yield the crude product. Finally, Guanfacine hydrochloride crystals are then filtered, dried, and then processed to form Guanfacine.
The major feedstocks for acetic Guanfacine are the precursor chemicals (2,6-dichlorophenylacetonitrile (I) etc.) and reagents (H2SO4, toluene etc.). The procurement of Guanfacine is majorly impacted by the price, market, or demand fluctuation in industries producing these chemicals. Any disruptions or fluctuations in the supply chain of these raw materials can affect the manufacturing process and ultimately the availability of guanfacine. Moreover, the accessibility and quality of these feedstocks can significantly influence the production and supply trends of Guanfacine in the market.
The project economic analysis provided in the report discusses a Germany-based plant:
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