Synthetic Menthol Production via Asymmetric Synthesis

This report presents a detailed cost analysis of synthetic menthol production from myrcene using a process involving asymmetric synthesis. In this process, firstly, an allylic amine is produced from myrcene, which undergoes hydrolysis process followed by asymmetric isomerisation using a BINAP rhodium complex to produce R-citronellal (which is enantiomerically pure). This is further cyclised through a carbonyl-ene-reaction started using zinc bromide to produce isopulegol. The isopulegol produced is finally hydrogenated to obtain synthetic menthol as the final product.

The project economic analysis provided in the report discusses a Germany-based plant:

• Manufacturing Process
  • Process Flow
  • Material Flow
  • Material Balance
• Raw Material and Product's Specifications
  • Raw Material Consumption
  • Product and Co-Product Generation
  • Capital Investment
• Land and Site Cost
  • Offsites/Civil Works
  • Equipment Cost
  • Auxiliary Equipment Cost
  • Contingency
  • Engineering and Consulting Charges
  • Working Capital
• Variable Cost
  • Raw Material
  • Utilities
• Fixed Cost
  • Labor Requirement & Wages
  • Overhead Expenses
  • Maintenance Charges
• Financing Costs
  • Interest on Working Capital
  • Interest on Loans
• Depreciation Charges
• General Sales and Admin Costs
• Production Cost Summary