The report provides a detailed analysis essential for establishing a Celecoxib production plant. It encompasses all critical aspects necessary for Celecoxib production, including the cost of Celecoxib production, Celecoxib plant cost, Celecoxib production costs, and the overall Celecoxib production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Celecoxib production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Celecoxib is a drug used to ease-of mild to moderate inflammation in the body. It acts by stopping the enzyme involved in the inflammatory response and decreasing the production of lipids that cause pain and inflammation. It is a nonsteroidal anti-inflammatory drug that is used in various inflammatory and pain-related conditions. It is used to reduce pain in adults due to rheumatoid arthritis and osteoarthritis. It is approved in primary dysmenorrhea for relieving severe menstrual cramps and associated discomfort with it.
Celecoxib is effective in treating acute pains like musculoskeletal pain and postoperative pain. It relieves chronic inflammation of the spine and stiffness in patients suffering from Ankylosing Spondylitis. It can be used to treat juvenile rheumatoid arthritis in children aged two years or older. Celecoxib is also used to reduce the number of precancerous polyps in the colon for patients having Familial Adenomatous Polyposis, reducing colorectal cancer risk.
The market of Celecoxib is driven by several key factors. Its use as a nonsteroidal anti-inflammatory drug for arthritis-associated pain results in its increasing demand. It is used to ease pain related to ankylosing spondylitis, musculoskeletal and postoperative pain, and acute pain, which further contributes to its demand. It is effective in managing juvenile rheumatoid arthritis in children aged two years or older.
The ongoing research into its potential applications due to its anticancer properties and effectiveness in treating migraines may also lead to increased demand. The developments in its demand as an anti-inflammatory drug, along with its cost-effectiveness as a generic medication, along with its production prices, market prices, and logistics, directly influence industrial Celecoxib procurement in market across the globe.
Raw Material for Celecoxib Production
According to the Celecoxib production plant project report, the key raw materials used in the production of Celecoxib include 4'-methyl acetophenone-ethyl trifluoroacetate-sodium ethoxide-(4-sulfamoyl phenylhydrazine hydrochloride).
Production Process of Celecoxib
The extensive Celecoxib production cost report consists of the following major industrial production process:
- From 4'-methyl acetophenone, ethyl trifluoroacetate, sodium ethoxide, and 4-sulfamoyl phenylhydrazine hydrochloride: The industrial production of Celecoxib consists of multiple steps. First, 4'-methyl acetophenone is reacted with ethyl trifluoroacetate in the presence of sodium ethoxide in a heated chamber. The above reaction creates 4,4,4-trifluoro-1-(4-methyl-phenyl)-butane-1,3-dione, which is further concentrated by evaporating the solvent. The concentrated compound is then reacted with 4-sulfamoyl phenylhydrazine hydrochloride with heating, which forms Celecoxib.
Celecoxib is a white to pale yellow solid in appearance. Its IUPAC name is 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide. Its molecular formula is C17H14F3N3O2S, and it has a molecular weight of 381.37 g/mol. It has a melting point of around 158-159°C. It has a very low solubility in water but shows better solubility in dimethyl sulfoxide (DMSO). Its density is around 1.43±0.1 g/cm³. It should be stored at a temperature range of 2-8°C to retain its stability for better applicability as an anti-inflammatory drug. These physical and chemical contribute to its anti-inflammatory action against a range of problems.
