Cilengitide Production Cost Reports

The report provides a detailed analysis essential for establishing a Cilengitide production plant. It encompasses all critical aspects necessary for Cilengitide production, including the cost of Cilengitide production, Cilengitide plant cost, Cilengitide production costs, and the overall Cilengitide production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Cilengitide production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Cilengitide is a synthetic small peptide drug that is used to block specific integrin proteins found on the surface of cancer cells and blood vessel cells that supply tumours. It helps cancer cells stick to surrounding tissues, form new blood vessels (angiogenesis), and spread to other parts of the body. It cuts off the blood supply that tumours need to grow and survive, which slows down disease progression and can trigger tumour cell death. It is also employed for the treatment of glioblastoma multiforme, where it is used in combination with radiation and chemotherapy for better results. It also shows benefits in treating other cancers like lung, prostate, head and neck, and skin cancers, as well as some blood cancers, because of its dual ability to prevent tumour growth and limit metastasis.

The market for Cilengitide is driven by the demand for better cancer treatments for aggressive tumours like glioblastoma. Its usage for fighting cancer by blocking integrins, proteins that help cancer cells grow and form blood vessels, boosts its market. Its utilisation in combination with cancer therapies and research into other diseases like lung, skin, and head and neck cancers makes it a preferred drug. The industrial Cilengitide procurement is affected by complex peptide synthesis that needs special raw materials and equipment, resulting in low yields and long production times. Also, the presence of only a few research-grade suppliers, along with supply risks like shipping delays, quality control issues, and higher costs, impacts its sourcing.

Raw Material for Cilengitide Production

According to the Cilengitide production plant project report, the key raw materials used in the production of Cilengitide include Fmoc-protected amino acids and Wang Resin.

Production Process of Cilengitide

The extensive Cilengitide production cost report consists of the following major industrial production process:

1. From Fmoc-protected amino acids and Wang Resin: The production of Cilengitide is done by a process called solid-phase peptide synthesis. The peptide chain is built one amino acid at a time on a solid resin. Protected amino acids are added in sequence, forming the desired linear chain. After the last amino acid is attached, protective groups are removed, and the peptide is cleaved from the resin using a solution of trifluoroacetic acid (TFA). The linear peptide is then cyclised, and its ends are joined to form a stable ring structure using either a chemical or enzyme-catalysed reaction. Finally, the product is purified using high-performance liquid chromatography (HPLC) and dried to get pure Cilengitide.

Cilengitide has the molecular formula of C27H40N8O7 and a molecular weight of 588.66 g/mol. It is a white to off-white lyophilised powder. It is a cyclic RGD pentapeptide (cyclo(RGDf-NMeVal)) with high hydrophilicity and a logP value of -2.5 and a topological polar surface area of 238 Ų. It has 7 hydrogen bond donors, 8 acceptors, and 4 defined stereocenters. It shows good water solubility with a density of around 1.42 g/cm³. It forms mixed hydrate-solvate crystals with alcohols like methanol and ethanol, showing pseudopolymorphism. It is stable as a solid at -20 degree Celsius and is administered intravenously in clinical formulations.