Gadoxetate Sodium Production Cost Reports

The report provides a detailed analysis essential for establishing a Gadoxetate Sodium production plant. It encompasses all critical aspects necessary for Gadoxetate Sodium production, including the cost of Gadoxetate Sodium production, Gadoxetate Sodium plant cost, Gadoxetate Sodium production costs, and the overall Gadoxetate Sodium production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Gadoxetate Sodium production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Gadoxetate Sodium is a specialised contrast agent used mainly in medical imaging, particularly in MRI scans of the liver. It is widely used as a contrast agent in diagnosing early-stage liver diseases because it is taken up by healthy liver cells, which allows abnormal areas to stand out more clearly on scans.

It helps doctors clearly visualise liver tissues, detect tumours, and evaluate conditions such as cirrhosis or bile duct disorders. It is also used in research facilities to study liver function and improve imaging techniques. Gadoxetate Sodium also serves as a useful tool, which supports treatment planning by helping clinicians monitor how liver diseases progress and how well patients respond to therapy.

The market for Gadoxetate Sodium is predominantly driven by its application as a contrast agent in medical imaging to detect abnormalities, which significantly promotes its demand in the medical sector. Its usage in liver MRI scans to detect liver tumours, lesions, and functional disorders further strengthens its demand among hospitals and advanced imaging centres. Its involvement as a useful tool for radiologists and healthcare professionals who need accurate information for diagnosis and treatment planning further promotes its demand in the healthcare and diagnostic sectors. Growing cases of chronic liver diseases, along with the rising need for accurate and early diagnosis, further increase their demand across healthcare systems.

Industrial Gadoxetate Sodium procurement is influenced by factors like the stability of raw material supply, adherence to strict regulatory standards, and quality requirements for pharmaceutical-grade contrast agents. Improvements in imaging technology, reliability of suppliers, and compliance with safety and environmental guidelines also influence its global demand and procurement decisions.

Raw Material for Gadoxetate Sodium Production

According to the Gadoxetate Sodium production plant project report, the major raw materials for Gadoxetate Sodium production include (S)-N-1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine Trihydrochloride and Haloacetic Acid.

Manufacturing Process of Gadoxetate Sodium

The extensive Gadoxetate Sodium production cost report consists of the following industrial production processes:

1. Production via Chemical Synthesis: The production process of Gadoxetate disodium begins with the alkylation of (S)-N-1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine trihydrochloride, where the amine groups are reacted with a haloacetic acid in the presence of sodium hydroxide. The haloacetic acids commonly used are bromoacetic, chloroacetic, or iodoacetic acid. The first step introduces the required carboxymethyl groups and leads to the formation of the chelating intermediate, (S)-2,2′-((2-((2-(bis(carboxymethyl)amino)-3-(4-ethoxyphenyl)propyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid. Then, the intermediate is combined with gadolinium(III) oxide in water along with sodium hydroxide, which allows the gadolinium ion to bind to the chelating framework and form the final gadolinium complex. Once the complexation is complete, the mixture is purified and dried to obtain Gadoxetate disodium as the final product.

Gadoxetate Sodium is commonly known as gadoxetate disodium. It is a gadolinium-based contrast agent that appears as a white to off-white solid without any characteristic odour. The molecular formula of the compound is C23H28GdN3Na2O11, and its molar mass is 725.72 g/mol. It is freely soluble in water, forming clear solutions. The material does not exhibit a melting point because it decomposes at high temperatures. The compound also does not have a true boiling point or flash point due to its non-volatile, thermally unstable nature. The IUPAC name of the compound is ethoxybenzyl-diethylenetriamine pentaacetic acid. It is handled as a hygroscopic solid that should be protected from moisture and elevated temperatures to maintain stability.