Ioversol Production Cost Reports

The report provides a detailed analysis essential for establishing a Ioversol production plant. It encompasses all critical aspects necessary for Ioversol production, including the cost of Ioversol production, Ioversol plant cost, Ioversol production costs, and the overall Ioversol production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Ioversol production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Ioversol is a medical contrast agent that finds extensive applications in medical imaging. It is primarily used to help doctors see blood vessels, organs, and tissues more clearly during imaging procedures. It is mainly given during CT scans and angiography to highlight problem areas like blockages, injuries, or abnormal growths. It is widely used in heart exams, brain scans, and abdominal studies to enhance the visibility of blood vessels, tissues, and organs. It is widely utilised during X-ray, CT, and angiographic procedures because it provides clear visibility. Ioversol is also used during certain kidney and urinary tract tests to help detect stones or structural issues.

The demand for Ioversol is predominantly driven by its application as a contrast agent in modern diagnostic imaging for accurate and effective radiographic studies, which significantly contributes to its market growth. Its application as an iodinated contrast agent in cardiovascular, neurological, and urinary tract examinations to provide clear and detailed images further enhances its demand in the medical and healthcare sectors. Its usage in hospitals and diagnostic centres for improving the accuracy of various scans, due to its quick action and good tolerance, also boosts its demand in the medical and diagnostic industries.

Moreover, the rising need for accurate diagnostic tools, coupled with the growth of hospitals, imaging centres, and advanced radiology services, further strengthens its market expansion. Additionally, factors such as the consistent availability of raw materials, production costs, strict regulatory standards, and the need for high-purity pharmaceutical-grade products strongly influence industrial Ioversol procurement on a global scale. Continuous technological advancements in imaging equipment, well-organised distribution channels, and evolving sustainability practices largely contribute to changes in procurement practices and help drive overall market growth.

Raw Material for Ioversol Production

According to the Ioversol production plant project report, the major raw materials for Ioversol production include 5 amino N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide and Chloroacetyl Chloride.

Production Process of Ioversol

The extensive Ioversol production cost report consists of the following industrial production process:

1. Production via Chemical Synthesis: The production process of Ioversol begins with 5 amino N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide as the starting material. This compound is first reacted with chloroacetyl chloride in a polar aprotic solvent to form a chloroacetylated intermediate. Then, the obtained intermediate is treated with a base to regenerate the dihydroxypropyl groups while retaining a chloroacetamido moiety. Further, the resulting compound undergoes an alkylation reaction in the presence of a base and water to introduce a hydroxyethyl group, which forms a hydroxyethylated intermediate. Finally, this intermediate is reacted in an aqueous solution with acetate ions, which leads to the formation of Ioversol as the final iodinated contrast agent.

Ioversol is a non-ionic, iodinated contrast agent that appears as an odourless white to off-white crystalline powder. The molecular formula of the compound is C18H24I3N3O9, and its molar mass is approximately 807.11 g/mol. The density of the solid is about 2.3 g/cm³. It has a melting point in the range of 180–182 degree Celsius, and it boils at around 864.9 degree Celsius under standard pressure. The flash point of the compound is estimated to be 476.9 degree Celsius. It is generally marketed as OPTIRAY®. The compound is sparingly soluble in water-miscible organic solvents such as DMSO and slightly soluble in methanol. It is relatively stable and hygroscopic, and standard precautions such as avoiding dust inhalation and using protective clothing are recommended during handling.