The report provides a detailed analysis essential for establishing an Isavuconazole production plant. It encompasses all critical aspects necessary for Isavuconazole production, including the cost of Isavuconazole production, Isavuconazole plant cost, Isavuconazole production costs, and the overall Isavuconazole production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Isavuconazole production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Isavuconazole is an azole antifungal compound that finds applications in the medical industry. It is an FDA-approved antifungal drug that is widely used for the treatment of invasive aspergillosis and invasive mucormycosis. Additionally, it also finds its application in the treatment of various severe fungal infections in patients who are immunocompromised.
The market for Isavuconazole is largely led by its application as an antifungal agent that is mainly used in the pharmaceutical industry due to its broad-spectrum antifungal activity. Moreover, its usage as an oral drug for the treatment of fungal infection in immunocompromised individuals further fuels its demand in the medical and pharmaceutical industries. Additionally, its employment as a medication for the treatment of aspergillosis and invasive mucormycosis effectively promotes its demand in the medical and healthcare industries. Furthermore, several factors largely influence industrial Isavuconazole procurement, such as the availability of raw materials, cost, and pricing, compliance with pharmaceutical regulations, quality standards, technological advancements, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.
Raw Material for Isavuconazole Production
According to the Isavuconazole production plant project report, the major raw materials for Isavuconazole production include 2-Halozincpropionate Ester.
Production Process of Isavuconazole
The extensive Isavuconazole production cost report consists of the following industrial production process:
- Production via Chemical synthesis: This method of production involves a Reformatsky reaction between a ketone and a 2-halozincpropionate ester in the presence of a solvent, which is further subjected to an enzymatic resolution step with an esterase enzyme to obtain isavuconazole through precipitation as the final product. Additionally, adding a non-protic apolar solvent like terfbutylmethylether or w-heptane can increase yield and speed up precipitation.
Isavuconazole serves as a triazole prodrug, has antifungal properties, and is water-soluble. The molecular formula of the compound is C22H17F2N5OS, and its molar mass is 437.5 g/mol. Moreover, the compound appears as an off-white to beige solid with a density of 1.38 g/cm3. The melting point of the compound is 89 – 91°C, and its boiling point is 678°C. Additionally, the compound is available in both oral and intravenous formulations. Its recommended storage temperature is between 2-8°C. It is slightly soluble in chloroform and methanol.
