Metamizole Sodium Production Cost Reports

The report provides a detailed analysis essential for establishing a Metamizole Sodium production plant. It encompasses all critical aspects necessary for Metamizole Sodium production, including the cost of Metamizole Sodium production, Metamizole Sodium plant cost, Metamizole Sodium production costs, and the overall Metamizole Sodium production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Metamizole Sodium production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Metamizole Sodium is also known as dipyrone and is widely recognized for its analgesic, anti-inflammatory, and antipyretic properties. It is widely used as an analgesic medication for the treatment of severe acute pain, such as post-operative pain, colic pain, and smooth muscle spasms. It also finds its application as an oral drug in relieving fever, pain, and inflammation. It is also used as an intermediate in the production of analgesic, anti-inflammatory, and antipyretic medications for various animals, including cattle, horses, pigs, sheep, dogs, and cats. It is often used in the form of injectable solutions in hospital and clinical settings to manage severe pain and high fever.

The market for Metamizole Sodium is predominantly driven by its demand as an analgesic and antipyretic drug for managing severe acute pain. Its usage as a non-narcotic analgesic drug for relieving pain associated with neuralgia, myalgia, acute arthritis, and post-operative pain also promotes its demand in the medical and pharmaceutical industries. Its application as an antipyretic drug for fever reduction, especially in cases where other treatments have proven ineffective, further enhances its demand in the pharmaceutical and healthcare industries.

Its involvement in production pain-relieving, anti-inflammatory, and fever-reducing medications for various animals also fuels its demand in the veterinary medicine industry. Metamizole sodium is subject to different regulations across different countries due to concerns over side effects, which largely impact its availability and industrial Metamizole Sodium procurement. Also, changes in the prices and availability of raw materials further affect the cost of Metamizole Sodium and its procurement strategies.

Raw Material for Metamizole Sodium Production

According to the Metamizole Sodium production plant project report, the major raw materials for Metamizole Sodium production include Acetoacetic Ester-Phenylhydrazine.

Production Process of Metamizole Sodium

The extensive Metamizole Sodium production cost report consists of the following industrial production process:

• Production via Chemical Synthesis: This method of production involves the synthesis of Metamizole Sodium by the chemical reaction of acetoacetic ester and phenylhydrazine to form 1-phenyl- 3-methylpyrazolone-5, followed by methylation with methyl iodide to give 1-phenyl- 2,3-dimethylpyrazolone-5. Further, the obtained compound undergoes nitrozation by sodium nitrite to form 1-phenyl-2,3-dimethyl-4- nitrozopyrazolone-5, followed by its reduction to give 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5. Then, the obtained compound is reacted with benzaldehyde to form 1-phenyl- 2,3-dimethyl-4-benzylidenaminopyrazolone-5, followed by methylation by dimethylsulfate to give quaternary salt, followed by hydrolysis to form 1-phenyl-2,3-dimethyl-4-methylaminopyrazolone-5. As the last step, the obtained product is treated with a water solution of a mixture of sodium bisulfite and formaldehyde, which results in the formation of 1-phenyl-2,3-dimethyl-4-methylaminopyrazolone-5-N-sodium methanesulfonate or Metamizole Sodium as the final product.

Metamizole Sodium is a pyrazolone derivative with the chemical formula C13H16N3NaO4S. The molecular weight of the compound is 333.339 g/mol. It exists in the form of a white to almost white crystalline powder that is very soluble in water and highly soluble in ethanol. The melting point of the compound ranges from 211°C to 216°C. Metamizole Sodium is unstable in the presence of light and contains 4.5 to 5.5% water as a monohydrate. The compound has a LogP of -0.82 and a strongest acidic pKa of -1.4. It contains 6 hydrogen acceptors, no hydrogen donors, a polar surface area of 83.99 Ų, 4 rotatable bonds, and 2 rings. The solution of the compound has a pH of 6.0-8.0.