The report provides a detailed analysis essential for establishing an Oxiconazole Nitrate production plant. It encompasses all critical aspects necessary for Oxiconazole Nitrate production, including the cost of Oxiconazole Nitrate production, Oxiconazole Nitrate plant cost, Oxiconazole Nitrate production costs, and the overall Oxiconazole Nitrate production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Oxiconazole Nitrate production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Oxiconazole Nitrate is a broad-spectrum imidazole known for its antifungal activity. It is widely used as a medication for the treatment of fungal skin infections in humans. Moreover, it also finds its application for the treatment of fungal infections caused due to dermatophytes, molds, yeasts, and gram-positive organisms. Additionally, it is also employed in the form of creams and powders to treat fungal skin infections topically.
The demand for Oxiconazole Nitrate is majorly driven by its application in the pharmaceutical industry as a conazole antifungal drug for the treatment of various fungal skin infections, which remarkably promotes its market growth. Moreover, its utilization in the form of topical antimycotic formulations to address fungal pathogens that affect humans further enhances its market growth. Additionally, variations in the cost and the availability of raw materials (DMF, NaH, etc.), regulatory compliance, pharmaceutical regulations, supplier reliability, sustainability practices, and efficient logistics impact industrial Oxiconazole nitrate procurement globally.
Raw Material for Oxiconazole Nitrate Production
According to the Oxiconazole Nitrate production plant project report, the major raw materials for Oxiconazole Nitrate production include 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone Oxime and Dimethylformamide (DMF) and Sodium Hydride.
Production Process of Oxiconazole Nitrate
The extensive Oxiconazole Nitrate production cost report consists of the following industrial production process:
- Production from a Ketone oxime: This method of production is initiated by an exothermic reaction of a ketone oxime with DMF and sodium hydride, followed by further steps that lead to the formation of oxiconazole as the product. In this method, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanone oxime is dissolved in dimethylformamide (DMF) and sodium hydride, followed by stirring and dropwise addition of 2,4-dichlorobenzyl chloride and again stirring it for 2 hours. Further, the reaction proceeds at a temperature of 80°C, followed by evaporating the obtained reaction mixture in a rotation evaporator under reduced pressure. As the last step, the reaction mixture is filtered to get rid of the undissolved matter and reacting it with nitric acid, which results in the formation of oxiconazole nitrate as the final product.
Oxiconazole Nitrate is an organic nitrate salt form of oxiconazole. The molecular formula of the compound is C18H14Cl4N4O4, and its molecular weight is 492.1 g/mol. The compound is mainly sold under the brand name of Oxistat. Moreover, the melting point of the compound is between 137-138°C, and it is recommended to be stored in a refrigerator. The compound exists in the form of an off-white crystalline solid that does not dissolve in water but is soluble in chloroform and sparingly soluble in methanol. The compound is mainly available in the form of creams and powders for the topical treatment of fungal infections.
