The report provides a detailed analysis essential for establishing a pioglitazone (Actos) production plant. It encompasses all critical aspects necessary for pioglitazone (Actos) production, including the cost of pioglitazone (Actos) production, pioglitazone (Actos) plant cost, pioglitazone (Actos) production costs, and the overall pioglitazone (Actos) production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a pioglitazone (Actos) production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Pioglitazone (Actos) is an FDA-approved medicine that is widely used in the medical and pharmaceutical industries. It is majorly utilized for the management and treatment of type 2 diabetes mellitus. Moreover, it finds its application as medication, along with proper diet and exercise, to regulate blood sugar levels and promote insulin sensitivity. Additionally, it is also employed in several clinical trials to demonstrate its efficacy and enhance its bioavailability.
The market for pioglitazone (Actos) is majorly driven by its broad usage as an antihyperglycemic for regulating blood sugar levels in patients with type 2 diabetes, which significantly promotes its demand in the medical and pharmaceutical industries. Moreover, its application as a medicine solely or in combination with other drugs for managing sugar levels in the blood by lowering insulin resistance further enhances its demand in the pharmaceutical industry.
Additionally, its employment for research activities and clinical trials effectively fuels its demand in the biotechnology and research & development industries. Furthermore, several factors influence industrial pioglitazone procurement, such as the availability of raw materials (Thiazolidine-2,4-dione, etc.), cost and pricing, compliance with medical and pharmaceutical regulations, quality standards, technological advancements, environmental considerations, sustainability practices, distribution (including trading and shipping), logistics, safety standards, etc.
Raw Material for Pioglitazone (Actos) Production
According to the Pioglitazone (Actos) production plant project report, the major raw materials for Pioglitazone (Actos) production include 4-[2-(5-ethyl-2-pyridinyl)-ethoxy]-Benzaldehyde-Thiazolidine-2,4-dione.
Production Process of Pioglitazone (Actos)
The extensive pioglitazone (Actos) production cost report consists of the following industrial production process:
- Production via Chemical Synthesis: This method of production is initiated by the chemical reaction of 4-[2-(5-ethyl-2-pyridinyl)-ethoxy]-benzaldehyde with a base, followed by its further reaction with thiazolidine-2,4-dione and the obtained product is then combined with hydrochloric acid to obtain a more stable salt of pioglitazone. The obtained product is further subjected to hydrogenation in the presence of a catalyst to obtain pioglitazone hydrochloride as the final product.
Pioglitazone (Actos) belongs to the class of thiazolidenediones. The IUPAC name of the compound is 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione. It is used as an anti-diabetic drug. This drug is often recognized by some other names, which include Zactos, Glustin, Piozone, and Pioglitazonum. Moreover, the molecular formula of the compound is C19H20N2O3S, and its molar mass is 356.4 g/mol. Its melting point is 183-184 °C, and it does not dissolve in water. Additionally, the compound, on heating, decomposes and releases hazardous products, including carbon dioxides, sulfur oxides, and nitrogen oxides.