Sulfapyridine Production Cost Reports

The report provides a detailed analysis essential for establishing a Sulfapyridine production plant. It encompasses all critical aspects necessary for Sulfapyridine production, including the cost of Sulfapyridine production, Sulfapyridine plant cost, Sulfapyridine production costs, and the overall Sulfapyridine production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Sulfapyridine production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Sulfapyridine is a sulfonamide antibiotic that treats dermatitis herpetiformis (Duhring's disease). It helps to manage itchy skin conditions linked to gluten sensitivity by reducing blistering and inflammation through immune modulation. It is prescribed for benign mucous membrane pemphigoid, which causes painful blisters on mucous membranes in the eyes, mouth, and genitals, helping control symptoms when other therapies fail.

It is also utilised for pyoderma gangrenosum and linear IgA disease, where it suppresses autoimmune blister formation effectively despite risks like crystallisation in urine. Its common side effects include nausea, vomiting, diarrhoea, headache, loss of appetite, photosensitivity rashes, itching, fever, and joint aches.

The market for Sulfapyridine is driven by growing needs in treating autoimmune skin conditions like dermatitis herpetiformis and mucous membrane pemphigoid. Its demand for sulfonamide antibiotics in resistant bacterial infections and research applications in biochemistry, molecular biology, and novel anti-inflammatory therapies boosts its demand.

The rising autoimmune disorders and antibiotic challenges through biotech advancements and clinical studies contribute to its market growth. The industrial Sulfapyridine procurement is influenced by the presence of GMP-certified suppliers with comprehensive USDMF, CEP, and WC documentation. Also, regulatory compliance from reliable global sources and the need for pharmaceutical-grade quality for formulations and lab use impact its sourcing.

Raw Material for Sulfapyridine Production

According to the Sulfapyridine production plant project report, the key raw materials used in the production of Sulfapyridine include p-nitrobenzenesulfonamide pyridine and nano iron powder.

Production Process of Sulfapyridine

The extensive Sulfapyridine production cost report consists of the following major industrial production process:

1. From p-nitrobenzenesulfonamide pyridine: The production process of Sulfapyridine starts with the reduction of p-nitrobenzenesulfonamide pyridine with nano iron powder and NH4Cl. The reduction takes place in methanol and is stirred at 80 degree Celsius for 3 hours. The reaction cools, dilutes with ethyl acetate, filters, and evaporates the filtrate to obtain a precipitate. Finally, water is added to basify with sodium bicarbonate to an alkaline pH to get Sulfapyridine as the final product.

Sulfapyridine appears as a white to off-white crystalline solid with a faint odour. It has the molecular formula of C11H11N3O2S and a molecular weight of 249.29 g/mol. It has a sulfonamide structure where a 4-aminobenzenesulfonamide group attaches to the 2-position of pyridine. It has a melting point at 191-193 degree Celsius and a boiling point of around 473 degree Celsius. It has a density of 1.32 g/cm³ with a refractive index of 1.67. It has low water solubility and slight solubility in DMSO and methanol. It exhibits a pKa value of 8.48 and a logP value in the range 0.35-1.47, making it moderately lipophilic. It has a topological polar surface area of 93.5 Ų with two hydrogen bond donors and five acceptors. It shows stability under normal conditions, though light-sensitive, combustible, and incompatible with strong oxidants.