Sulfathiazole Production Cost Reports

The report provides a detailed analysis essential for establishing a Sulfathiazole production plant. It encompasses all critical aspects necessary for Sulfathiazole production, including the cost of Sulfathiazole production, Sulfathiazole plant cost, Sulfathiazole production costs, and the overall Sulfathiazole production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a Sulfathiazole production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Sulfathiazole is a short-acting sulfonamide antibiotic that is used to treat different bacterial infections. It is utilised in infections caused by streptococci and staphylococci. It is used topically, where it is combined with other sulfonamides like sulfonamide and sulfacetamide in creams, pessaries, or powders.

It manages local treatment of vaginal infections, selected skin infections, and eye infections with sulfathiazole sodium preparations. It is also used as a veterinary antibiotic for livestock and pets to control different bacterial infections. It is also utilised in research settings as a model sulfonamide to study antimicrobial mechanisms, endocrine-disrupting effects, and environmental impact in aquatic organisms. Its common side effects include nausea, vomiting, diarrhoea, headache, loss of appetite, and skin rashes from photosensitivity or hypersensitivity.

The market for Sulfathiazole is driven by increasing infectious diseases. Its utilisation, because of rising bacterial and urinary tract infections, boosts its demand. Also, its use as a veterinary antibiotic for livestock and pets, and growing respiratory infection treatments, contribute to its market growth.

The need for GMP-certified suppliers delivering USDMF, JDMF, KDMF, CEP, and WC credentials, including impurity controls, pharmacopoeia standards, and veterinary compliance, impacts industrial Sulfathiazole procurement. The cost fluctuations, supply reliability, quality audits, and regional regulations, like the FDA and EMA, to ensure formulation safety, further add to its procurement costs. The Asia-Pacific region leads its API production for affordable high volumes, while Europe and North America provide premium research-grade materials, prompting buyers to prioritise sustainable practices.

Raw Material for Sulfathiazole Production

According to the Sulfathiazole production plant project report, the key raw materials used in the production of Sulfathiazole include 2-aminothiazole, p-acetamidobenzenesulfonyl chloride, and sodium chloride.

Production Process of Sulfathiazole

The extensive Sulfathiazole production cost report consists of the following major industrial production process:

1. From 2-aminothiazole: The Sulfathiazole production has a two-phase reaction system from 2-aminothiazole and p-acetamidobenzenesulfonyl chloride to form the bis-intermediate di-(p-acetamidobenzenesulfonyl)-2-aminothiazole. Selective hydrolysis with 26-28% aqueous ammonia at 65 degree Celsius for 2-2.5 hours cleaves one sulfonyl group, precipitating N-acetylsulfanilamide while retaining N-acetylsulfathiazole in the filtrate. Final deacetylation takes place by dissolving N-acetylsulfathiazole in NaOH, and neutralising or acidifying to separate pure Sulfathiazole.

Sulfathiazole appears as a white to cream-coloured crystalline powder with a slight odour. It has a molecular formula of C9H9N3O2S2 and a molecular weight of 255.32 g/mol. It has a sulfonamide bridge between p-aminobenzene and 2-aminothiazole rings. It has a melting point at 202-205 degree Celsius with a density of 1.49 g/cm³. It has a refractive index of 1.65 and low water solubility. It shows good solubility in acetone and DMF. It inhibits folate synthesis via PABA mimicry, exhibits two H-bond donors, six acceptors, three rotatable bonds, and moderate complexity. It has light sensitivity (darkens slowly) and is incompatible with strong oxidants, acids, and bases.