Sulfisoxazole Production Cost Reports

The report provides a detailed analysis essential for establishing a sulfisoxazole production plant. It encompasses all critical aspects necessary for sulfisoxazole production, including the cost of sulfisoxazole production, sulfisoxazole plant cost, sulfisoxazole production costs, and the overall sulfisoxazole production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a sulfisoxazole production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Sulfisoxazole is a short-acting sulfonamide antibiotic that stops bacterial folic acid synthesis. It works by blocking dihydropteroate synthetase, effective against various gram-positive and gram-negative pathogens. It is utilised for severe, recurrent, or chronic urinary tract infections like pyelonephritis and cystitis, nocardiosis, and acute otitis media. It is also used in toxoplasmosis (with pyrimethamine), chancroid, trachoma, and inclusion conjunctivitis, as well as adjunctive therapy for chloroquine-resistant malaria or meningococcal prophylaxis. It is utilised in Haemophilus influenzae meningitis (with streptomycin), lymphogranuloma venereum, and Chlamydia trachomatis infections. Its common side effects include nausea, vomiting, diarrhoea, loss of appetite, headache, and dizziness.

The market for sulfisoxazole is driven by its usage as a short-acting sulfonamide antibiotic. The rise in demand in resource-limited regions for affordable treatment of urinary tract infections, nocardiosis, toxoplasmosis, acute otitis media, etc., contributes to its market growth. The low generic production volumes, elevating per-unit costs despite straightforward chemical synthesis and reliance on Asian API suppliers impacts industrial sulfisoxazole procurement. Other factors, like volatile prices for sulfonamide precursors because of environmental production regulations and regulatory restrictions from sulfa allergy risks, impact its sourcing. The global antibiotic stewardship programs reduce usage and expose supply weaknesses from quality problems, which also impacts their market dynamics.

Raw Material for Sulfisoxazole Production

According to the sulfisoxazole production plant project report, the key raw materials used in the production of sulfisoxazole include 3,4-Dimethyl-5-aminoisoxazole, 4-acetamidobenzenesulfonyl chloride, and pyridine.

Production Process of Sulfisoxazole

The extensive sulfisoxazole production cost report consists of the following major industrial production process:

1. From 3,4-Dimethyl-5-aminoisoxazole: Sulfisoxazole is manufactured via a standard sulfonamide synthesis route. First, 3,4-dimethyl-5-aminoisoxazole is reacted with 4-acetamidobenzenesulfonyl chloride in a solvent mixture like pyridine and acetone. The reaction takes place at a controlled temperature to form the N-acetyl protected sulfonamide intermediate. The intermediate is isolated by adding water, followed by hydrolysis and treating with NaOH to get sulfisoxazole.

Sulfisoxazole has the molecular formula of C11H13N3O3S and a molecular weight of 267.3 g/mol. It appears as a white-to-light-brown, odourless, and slightly bitter crystalline solid.  It has a melting point of 195 degrees Celsius and a boiling point of around 482 degrees Celsius. It has a density of 1.35 g/cm³ and a refractive index of 1.66. It shows low water solubility but good solubility in acetone. It has a pKa value of 5.0, XLogP3 of 1.0, and topological polar surface area of 107 Ų. It has 2 hydrogen bond donors, 6 acceptors, 3 rotatable bonds, and 18 heavy atoms.