Ticlopidine Production Cost Reports

The report provides a detailed analysis essential for establishing a ticlopidine production plant. It encompasses all critical aspects necessary for ticlopidine production, including the cost of ticlopidine production, ticlopidine plant cost, ticlopidine production costs, and the overall ticlopidine production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating a ticlopidine production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.

Ticlopidine is an oral antiplatelet drug that stops platelet aggregation by blocking ADP receptors. It is used to prevent thrombotic strokes in patients who have experienced a prior stroke, transient ischemic attack (TIA), or warning signs and cannot tolerate aspirin. It is also prescribed with aspirin to prevent clot formation in coronary stents after placement.

It proves more effective than aspirin alone in maintaining vessel patency. It is also used in pre-open heart surgery, sickle cell disease, certain kidney disorders like glomerulonephritis, and peripheral artery disease to reduce clotting risks. It is given 250 mg twice daily with food, requiring blood monitoring. Its common side effects include diarrhoea, nausea, rash, dizziness, stomach upset, and headache.

The market for ticlopidine is driven by increasing stroke cases. The rise in ageing populations and public health initiatives promoting cheap generic antiplatelets among aspirin-allergic patients boosts its demand. Low production costs in certain regions, generic approvals, and rising access to cardiovascular care in developing areas support its market.

The industrial ticlopidine procurement is influenced by basic generic pill focuses on low-price hospital and pharmacy bulk deals, plus government tenders in budget-limited markets. Also, quality certifications and stable raw material flows, along with factors like mandatory blood tests for risks like low white cells or clotting disorders impacts its market dynamics.

Raw Material for Ticlopidine Production

According to the ticlopidine production plant project report, the key raw materials used in the production of ticlopidine include 2-thiophenecarboxaldehyde and nitromethane.

Production Process of Ticlopidine

The extensive ticlopidine production cost report consists of the following major industrial production process:

1. From 2-thiophenecarboxaldehyde and nitromethane: The production process of ticlopidine involves several steps. It starts with Henry condensation of 2-thiophenecarboxaldehyde and nitromethane in ethanol with ammonium acetate and acetic acid reflux that forms the nitroalkene. This is followed by reduction with LiAlH4 in THF that gives 2-(2-thienyl)ethylamine. The cyclisation with formaldehyde and HCl, followed by basification and extraction, gives 4,5,6,7-tetrahydrothieno[3,2-c]pyridine. Finally, N-alkylation with 2-chlorobenzyl chloride, K2CO3 in acetonitrile, followed by purification, gives ticlopidine as the final product.

Ticlopidine’s free base has the molecular formula of C14H14ClNS with a molecular weight of 263.79 g/mol. Its hydrochloride salt has the molecular formula of C14H15Cl2NS with a molecular weight of  300.22 g/mol. It appears as a white to off-white crystalline powder with a faint odour. It shows limited aqueous solubility, but high solubility in polar organic solvents like methanol, ethanol, dichloromethane, and chloroform, with low solubility in acetone and ether. It has a logP value of 3.2 that makes it moderately lipophilic. It is chemically stable under ambient conditions, non-hygroscopic when properly stored, resistant to hydrolysis but susceptible to oxidation, forming N-oxides. It shows 98% plasma protein binding and hepatic metabolism primarily via CYP2C19/CYP3A4 to inactive thiol metabolites.