The report provides a detailed analysis essential for establishing an Acetrizoate production plant. It encompasses all critical aspects necessary for Acetrizoate production, including the cost of Acetrizoate production, Acetrizoate plant cost, Acetrizoate production costs, and the overall Acetrizoate production plant cost. Additionally, the study covers specific expenditures associated with setting up and operating an Acetrizoate production plant. These encompass production processes, raw material requirements, utility requirements, infrastructure needs, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, and more.
Acetrizoate is used as a radiographic contrast agent to enhance the visibility of internal body structures during X-ray imaging procedures. It is employed in urography to visualise the urinary tract, including kidneys, ureters, and bladder, and in angiography to image blood vessels such as the brain, carotid arteries, and aorta. The iodine atoms in Acetrizoate absorb X-rays effectively, creating contrast between different tissues, which helps in the diagnosis of abnormalities like blockages, tumours, and vascular diseases. Its water solubility allows it to be administered intravenously or via other routes, depending on the imaging target. It has high osmolality that is associated with risks like nephrotoxicity and adverse reactions but remains important for imaging needs and research.
The Acetrizoate market is driven by the growing global demand for diagnostic imaging. Its utilisation in procedures like urography and angiography, which require effective radiographic contrast agents, contributes to its market growth. The rising prevalence of chronic diseases, expansion of healthcare infrastructure, increased investment in diagnostic centres, and technological advancements in medical imaging fuel its demand. The focus on early diagnosis and preventative medicine also boosts its utilisation as an imaging contrast agent.
The industrial Acetrizoate procurement is influenced by factors like strict regulatory approvals ensuring safety and efficacy, supplier reliability to maintain consistent availability, and its safety profile, which impacts demand due to potential side effects. Also, procurement policies involving competitive tenders, healthcare infrastructure readiness, and storage requirements further affect sourcing.
Raw Material for Acetrizoate Production
According to the Acetrizoate production plant project report, the key raw materials used in the production of Acetrizoate include 3-Amino-2,4,6-Triiodobenzoic Acid-Acetic Anhydride-Sulfuric Acid.
Production Process of Acetrizoate
The extensive Acetrizoate production cost report consists of the following major industrial production process:
- From 3-Amino-2,4,6-Triiodobenzoic Acid and Acetic Anhydride: The production process of Acetrizoate involves a reaction between 3-Amino-2,4,6-Triiodobenzoic Acid and Acetic Anhydride. First, 3-Amino-2,4,6-triiodobenzoic acid is refluxed with acetic anhydride and a few drops of sulfuric acid for 30 minutes. After cooling, the mixture was poured into water to crystallise. The resulting product is a mixed anhydride of 3-acetylamino-2,4,6-triiodobenzoic acid, which is filtered, washed, and hydrolysed with ammonium hydroxide. The solution is treated with activated carbon, acidified with hydrochloric acid, filtered, washed, and dried to obtain 3-acetylamino-2,4,6-triiodobenzoic acid. This compound was then neutralised with sodium hydroxide, evaporated, and dried to get the sodium salt of Acetrizoate as the final product.
Acetrizoate is a white crystalline solid that is water-soluble and characterised by high osmolality. It has a molecular formula of C9H6I3NO3 and a molecular weight of 556.86 g/mol. It has three iodine atoms, which provide high atomic density essential for X-ray attenuation in medical imaging. It has a melting point around 280 degree Celsius (with decomposition) and a boiling point near 547 degree Celsius. It shows moderate lipophilicity with a logP value of about 1.04 and a polar surface area of 66.4 Ų. It is administered intravenously in water-soluble form for imaging applications like urography and angiography. All these physical and chemical properties make it an effective radiographic contrast agent.