Hippuric Acid Manufacturing Plant Project Report: Key Insights and Outline

Hippuric Acid Manufacturing Plant Project Report by Procurement Resource thoroughly focuses on every detail that encompasses the cost of manufacturing. Our extensive cost model meticulously covers breaking down Hippuric Acid plant capital cost around raw materials, labour, technology, and manufacturing expenses. This enables precise cost structure optimisation and helps in identifying effective strategies to reduce the overall Hippuric Acid manufacturing plant cost and the cash cost of manufacturing.

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Hippuric Acid is a naturally occurring organic acid. It is a normal product found in the urine of many animals, especially herbivores. It forms when benzoic acid is combined with glycine in the liver. It appears as white crystalline needles or a powder. Hippuric Acid is mainly used as a chemical intermediate and in some specialised areas.
 

Its industrial uses, by estimated industry proportion, are:

• Pharmaceutical Intermediates (50-60%): Hippuric Acid serves as a building block for making various pharmaceutical compounds. It is used in the synthesis of certain drugs or their derivatives.
• Speciality Chemicals and Research (20-25%): It is used as a fine chemical in various laboratory applications. It also finds use in research studies related to metabolism and toxicology.
• Analytical Reagent (10-15%): Hippuric Acid can be used in analytical chemistry. It acts as a standard or a reagent in some tests.
• Nutritional Supplements (5-8%): Though less common than other forms, it can be found in some supplements as a source of benzoic acid and glycine, often related to gut health.
• Other Niche Uses (2-5%): This includes minor uses in certain industrial formulations.
   

Top Manufacturers of Hippuric Acid:

Hippuric Acid is made by fine chemical companies and research chemical suppliers.

• Sigma-Aldrich (Merck KGaA) (Germany, Global)
• TCI Chemicals (India) Pvt. Ltd. (India, Global)
• Alfa Aesar (Thermo Fisher Scientific) (USA, Global)
• Cayman Chemical Company (USA, Global)
• Hangzhou Dayangchem Co., Ltd. (China)
   

Feedstock for Hippuric Acid and Value Chain Dynamics

The industrial manufacturing process of Hippuric Acid mainly uses glycine and benzoyl chloride as the starting raw materials. Sodium hydroxide (NaOH) or triethylamine is used as a base, and a strong acid is also used in a later step.

• Glycine Sourcing: Glycine is the simplest amino acid. It is produced through various chemical methods, such as the Strecker amino acid synthesis (from ammonia, formaldehyde, and hydrogen cyanide) or by enzymatic processes.
  • Petrochemical/Biotech Prices: The cost of glycine depends on the prices of its precursors (often petrochemicals). It also depends on the efficiency of biotech processes. Market price fluctuation in these areas impacts the production cost for glycine, which in turn affects the Hippuric Acid manufacturing plant cost.
• Benzoyl Chloride Sourcing: Benzoyl chloride is an organic acid chloride. It is usually produced by reacting benzoic acid with thionyl chloride or phosphorus pentachloride. It can also be synthesised from toluene.
  • Benzene/Toluene Prices: Benzoyl chloride costs are linked to the prices of toluene or benzene. These are basic petrochemicals. Changes in these raw materials directly impact the production cost for Hippuric Acid.
  • Hazardous Nature: Benzoyl chloride is corrosive and reactive, which adds to its storage and handling costs and safety measures.
• Sodium Hydroxide (NaOH) or Triethylamine Sourcing: These are used as a base. NaOH is a commodity chemical, and triethylamine is a speciality chemical.
  • Energosts (for NaOH)y C: Caustic soda production uses a lot of electricity. Changes in electricity prices impact its cost, affecting operating expenses (OPEX).
  • Speciality Pricing (for Triethylamine): Triethylamine is more expensive. Its use is based on specific process needs and economic feasibility.
• Strong Acid Sourcing: A strong acid, such as hydrochloric acid (HCl) or sulfuric acid (H2SO4), is used in a later step.
  • Commodity Chemical Prices: These acids are common industrial chemicals. Their prices are generally stable but can be affected by sulfur prices (for sulfuric acid) or chlorine prices (for hydrochloric acid).
     

Market Drivers for Hippuric Acid

The market for Hippuric Acid is driven by its use in pharmaceutical and speciality chemical industries. This leads to steady consumption in niche applications.

• Demand as Pharmaceutical Intermediate: Hippuric Acid is a building block for various drugs and their derivatives. The ongoing growth in the pharmaceutical sector drives a consistent demand for such fine chemical intermediates.
• Growth in Speciality Chemical Synthesis: Its unique chemical structure makes it valuable for making specific compounds needed in various industrial applications. This specialised demand supports its production.
• Applications in Research and Analytical Fields: Hippuric Acid is used in academic and industrial research for metabolism studies. Its usage as an analytical standard or reagent also contributes to stable consumption.
• Specific Health Applications (Niche): While not a major driver, its occasional use in supplements related to detoxification processes or gut health provides a small but growing market segment.
• Regional Consumption and Production:
  • Asia-Pacific (APAC): This region is a growing centre for fine chemical and pharmaceutical intermediate production (China, India). Expanding pharmaceutical manufacturing drives demand. The Hippuric Acid manufacturing plant cost here can be lower due to feedstock availability and competitive labour costs.
  • North America and Europe: They have steady demand for high-purity Hippuric Acid for pharmaceutical synthesis and advanced research, focusing on modernising plants for higher efficiency and meeting strict quality rules.
     

CAPEX (Capital Expenditure) for a Hippuric Acid Plant

The Hippuric Acid plant capital cost involves specialised chemical reaction and purification equipment. Handling corrosive and reactive chemicals requires strict safety measures.

• Land and Site Preparation (5-8% of total CAPEX):
  • This includes space for process units and safety areas.
  • Consists of foundations for reactors and tanks, roads, drainage, and utility hook-ups.
• Raw Material Storage and Handling (10-15%):
  • Storage Tanks: Tanks for liquid feedstock (e.g., benzoyl chloride, sodium hydroxide solution, strong acids, triethylamine if used). Tanks must be corrosion-resistant.
  • Solid Storage: Bins or hoppers for solid glycine. Includes accurate dosing systems.
  • Pumps and Piping: Chemical-resistant pumps and piping for moving all liquids.
• Reaction Section 1 (Amide Formation) (20-25%):
  • Reactor Vessel: A jacketed, agitated reactor (often glass-lined or speciality alloy for corrosion resistance) where glycine and benzoyl chloride react. It needs precise temperature control.
  • Cooling Systems: For managing the heat released during the reaction.
  • HCl Gas Scrubber: System to absorb and neutralise hydrochloric acid (HCl) gas released as a byproduct. This is important for safety and environmental compliance.
• Solid-Liquid Separation (Intermediate) (5-8%):
  • Filters/Centrifuges: To separate the N-benzoyl glycine intermediate if it precipitates. This ensures purity for the next step.
• Reaction Section 2 (Acid Workup / Protonation) (10-15%):
  • Acidification Reactor: A vessel for reacting the N-benzoyl glycine intermediate with a strong acid. This step protonates the amino group.
  • Heating/Cooling Systems: To control the temperature of this reaction.
• Purification Section (25-35%): This is often the most capital-intensive part, especially due to crystallisation and drying for high purity.
  • Crystallisers: Jacketed vessels with controlled cooling for forming pure Hippuric Acid crystals from solution.
  • Centrifuges/Filters: For efficient solid-liquid separation of crystalline Hippuric Acid from mother liquor.
  • Washing Stations: Systems for thorough washing of the product cake to remove residual impurities and salts.
  • Drying Equipment: Vacuum dryers or tray dryers to remove residual moisture from the crystals.
• Product Storage and Packaging (5-8%):
  • Finished Product Storage: Bins or silos for solid Hippuric Acid.
  • Packaging Machines: Automated bagging machines for bags or bulk containers.
  • Warehousing: Covered space for storing finished products.
• Utilities and Support Systems (10-15%):
  • Steam Generation: Boilers and pipes for steam to heat reactors and dryers.
  • Cooling Water Systems: Cooling towers, chillers, and pipes for process cooling.
  • Compressed Air: For instruments and utility air.
• Instrumentation and Control Systems (5-8%):
  • Automated Controls: Central control rooms with advanced systems (like DCS or PLCs). They watch and control all process factors (temperature, pH, flow, pressure) in real-time.
  • Process Analysers: Online pH meters, conductivity meters, and lab equipment (HPLC, titration) to check purity and reaction progress.
• Laboratory Facilities (2-3%):
  • Labs with testing tools for checking raw materials, in-process quality, and final product purity.
• Safety and Environmental Systems (5-8%):
  • Acid fume scrubbers (for HCl), spill containment, emergency showers/eyewashes.
  • Waste neutralisation and disposal systems.
     

OPEX (Operating Expenses) for a Hippuric Acid Plant:

• Raw Material Costs (50-65% of total OPEX):
  • Glycine: Cost per ton.
  • Benzoyl Chloride: Cost per ton.
  • Sodium Hydroxide (or Triethylamine): Cost per ton.
  • Strong Acid (e.g., HCl, H2SO4): Cost per ton.
  • Other Chemicals: Any solvents used (if not fully recycled), purification aids.
• Energy Costs (15-20%): The process uses energy for heating reactions and drying.
  • Steam: For heating reactors and dryers.
  • Electricity: For running pumps, agitators, centrifuges, and controls.
  • Cooling Water: For condensers and process cooling.
• Labour Costs (8-12%):
  • Wages, benefits, and training for skilled plant workers: operators, chemical engineers, quality control technicians, maintenance staff.
• Consumables and Spares (3-5%):
  • Replacement parts for pumps, agitators, and filters/centrifuges.
  • Lab chemicals for testing.
  • Packaging materials.
• Maintenance and Repairs (3-4%):
  • Regular checks and fixes for all machines, especially corrosion-resistant equipment.
  • Fixing sudden problems to avoid stopping production.
• Utilities (Non-Energy) (1-2%):
  • Water for process, cooling, and washing. Includes water treatment costs.
  • Compressed air.
• Environmental Costs and Waste Disposal (2-3%):
  • Costs to run HCl gas scrubbers.
  • Costs to run wastewater treatment plants (ETP) for acidic and organic effluents.
  • Fees for disposing of any chemical waste or off-spec products.
  • Permit fees and monitoring for environmental rules.
• Byproduct Credit/Cost: Managing byproduct HCl can either add cost (disposal) or provide minor credit (recovery for sale/reuse).
• Overhead and Admin Costs (2-3%):
  • General office costs, insurance (often high for chemical plants), property taxes, R&D for better products, and sales/marketing.
     

Manufacturing Process of Hippuric Acid

This report provides a value chain evaluation for Hippuric Acid manufacturing. It also includes a detailed production cost analysis revolving around industrial Hippuric Acid manufacturing. Hippuric Acid is made through a chemical reaction involving an amino acid.
 

Production from Glycine and Benzoyl Chloride:

The industrial manufacturing process of Hippuric Acid starts with glycine and benzoyl chloride as the starting raw materials. Glycine and benzoyl chloride react in the presence of sodium hydroxide (NaOH) or triethylamine as a base to form an N-benzoyl glycine intermediate. This reaction also releases hydrochloric acid (HCl). The intermediate is then reacted with a strong acid, which leads to the protonation of the amino group. This final step produces Hippuric Acid as the product.
 

Properties of Hippuric Acid

• Chemical Formula: C9H9NO3
• Appearance: It is a white crystalline needle or powder.
• Odour: It is odourless.
• Melting Point: It has a melting point of 188 degree Celsius (370 degree Fahrenheit).
• Solubility: It is slightly soluble in cold water and more soluble in hot water, ethanol, and diethyl ether. However, it is insoluble in petroleum ether.
• Acidity: It is a weak acid.
• Stability: It is generally stable under normal conditions. It can be hydrolysed (broken down with water) in the presence of strong acids or bases to form benzoic acid and glycine.
• Biological Significance: It is a metabolic product. It is formed in the body when benzoic acid is detoxified.
• Hippuric Acid's specific chemical structure makes it useful in synthesising other compounds. Its should cost of production is influenced by its raw material costs and complex synthesis steps. However, its specialised demand ensures its economic feasibility.

 
Hippuric Acid Manufacturing Plant Report provides you with a detailed assessment of capital investment costs (CAPEX) and operational expenses (OPEX), generally measured as cost per metric ton (USD/MT). This approach ensures that your investment decisions are aligned with the latest industry standards and economic feasibility metrics, enhancing your manufacturing efficiency and financial planning

Apart from that, this Hippuric Acid manufacturing plant report also covers the leading technology providers that help you plan a robust plan of action related to Hippuric Acid manufacturing plant and its production process, and also by helping you with an in-depth supplier database. This report provides exclusive insights into the best manufacturing practices for Hippuric Acid and technology implementation costs. This report also covers operational cash flow, fixed and variable costs, and detailed break-even point analysis, ensuring that your manufacturing process is not only efficient but also economically viable in the competitive market landscape.

In addition to operational insights, the Hippuric Acid manufacturing plant report also comprehensively focuses on lifecycle cost analysis, maintenance costs, and energy consumption costs, which are critical for maintaining long-term sustainability and profitability. Our manufacturing cost analysis extends to include regulatory compliance costs, inventory holding costs, and logistics and distribution costs, providing a holistic view of the potential expenses and savings.

We at Procurement Resource ensure that this report is not only cost-efficient, environmentally sustainable, and aligned with the latest technological advancements but also that you are equipped with all necessary tools to optimise supply chain operations, manage risks effectively, and achieve superior market positioning for Hippuric Acid.
 

Key Insights and Report Highlights

Key Questions Covered in our Hippuric Acid Manufacturing Plant Report

• How can the cost of producing Hippuric Acid be minimised, cash costs reduced, and manufacturing expenses managed efficiently to maximise overall efficiency?
• What is the estimated Hippuric Acid manufacturing plant cost?
• What are the initial investment and capital expenditure requirements for setting up a Hippuric Acid manufacturing plant, and how do these investments affect economic feasibility and ROI?
• How do we select and integrate technology providers to optimise the production process of Hippuric Acid, and what are the associated implementation costs?
• How can operational cash flow be managed, and what strategies are recommended to balance fixed and variable costs during the operational phase of Hippuric Acid manufacturing?
• How do market price fluctuations impact the profitability and cost per metric ton (USD/MT) for Hippuric Acid, and what pricing strategy adjustments are necessary?
• What are the lifecycle costs and break-even points for Hippuric Acid manufacturing, and which production efficiency metrics are critical for success?
• What strategies are in place to optimise the supply chain and manage inventory, ensuring regulatory compliance and minimising energy consumption costs?
• How can labour efficiency be optimised, and what measures are in place to enhance quality control and minimise material waste?
• What are the logistics and distribution costs, what financial and environmental risks are associated with entering new markets, and how can these be mitigated?
• What are the costs and benefits associated with technology upgrades, modernisation, and protecting intellectual property in Hippuric Acid manufacturing?
• What types of insurance are required, and what are the comprehensive risk mitigation costs for Hippuric Acid manufacturing?