N-Acetylsulfanilyl Chloride Manufacturing Plant Project Report: Key Insights and Outline

N-Acetylsulfanilyl Chloride Manufacturing Plant Project Report by Procurement Resource thoroughly focuses on every detail that encompasses the cost of manufacturing. Our extensive cost model meticulously covers breaking down N-Acetylsulfanilyl Chloride plant capital cost around raw materials, labour, technology, and manufacturing expenses. This enables precise cost structure optimisation and helps in identifying effective strategies to reduce the overall N-Acetylsulfanilyl Chloride manufacturing plant cost and the cash cost of manufacturing.

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N-Acetylsulfanilyl Chloride is a chemical compound that appears as a white to light grey crystalline powder. This compound is an important intermediate and plays a crucial role in making sulfa drugs, which are medicines used to fight bacterial infections. It also finds use in creating a range of colours for textiles and plastics.

• Pharmaceutical Intermediates (65-75%): N-Acetylsulfanilyl Chloride is a primary building block for synthesising sulfanilamide and its derivatives. These are essential for producing sulfa drugs, used in treating various bacterial infections.
• Dyes and Pigments (10-15%): It serves as an intermediate in the production of certain dyes and pigments. These are used in textiles, paints, and plastics to create specific colours.
• Speciality Chemicals and Research (8-12%): This compound is valuable as a fine chemical for various laboratory applications and chemical synthesis. It is used as a reagent in certain analytical tests and experiments.
• Other Niche Applications (3-5%): Minor uses may exist in areas like agrochemical intermediates or other specialised chemical processes.
   

Leading Manufacturers of N-Acetylsulfanilyl Chloride:

Speciality chemical companies and pharmaceutical intermediate producers are the main manufacturers of N-Acetylsulfanilyl Chloride:

• Merck KGaA (Sigma-Aldrich) (Germany, Global)
• TCI Chemicals (India) Pvt. Ltd. (India, Global)
• Alfa Aesar (Thermo Fisher Scientific) (USA, Global)
• Junsei Chemical Co., Ltd. (Japan, Global)
• Anqiu Hualong Chemical Co., Ltd. (China)
   

Feedstock and Supply Chain Dynamics for N-Acetylsulfanilyl Chloride Production

The industrial manufacturing process for N-Acetylsulfanilyl Chloride primarily uses acetanilide and chlorosulfonic acid as its key raw materials.

• Acetanilide Sourcing: Acetanilide is an organic compound produced by reacting aniline with acetic anhydride. Aniline itself is derived from the hydrogenation of nitrobenzene.
  • Upstream Petrochemical Influence: Acetanilide's cost is affected by prices of benzene or toluene (for aniline) and acetic acid (for acetic anhydride). Thus, fluctuations in the prices of these commodities directly impact the cash cost of production for acetanilide, which influences the overall N-Acetylsulfanilyl Chloride manufacturing plant cost.
• Chlorosulfonic Acid Sourcing: Chlorosulfonic acid is a highly reactive and corrosive chemical. It is produced by reacting sulfur trioxide (from sulfuric acid production) with hydrogen chloride.
  • Sulfur, Chlorine, and Energy Costs: Its cost is linked to the prices of sulfur (for sulfuric acid), chlorine, and the electricity needed for chlorine production.
  • Handling Challenges: Chlorosulfonic acid is very corrosive. Its storage and handling require specialised, resistant equipment and strict safety measures. This adds to fixed and variable costs in the production process.
• Energy Inputs: The reaction between acetanilide and chlorosulfonic acid occurs at high temperatures. Additionally, subsequent purification steps also require energy.
  • Utility Costs: Heating for the reaction and drying, plus electricity for pumps and cooling, form a notable part of operating expenses (OPEX).
     

Market Drivers for N-Acetylsulfanilyl Chloride

The market for N-Acetylsulfanilyl Chloride experiences consistent expansion driven by strong demand from the global pharmaceutical and dye industries. This leads to increasing consumption in many specialised applications.

• Growth in Pharmaceutical Manufacturing: N-Acetylsulfanilyl Chloride is an important intermediate for producing sulfa drugs, which combat bacterial infections. The increasing global demand for pharmaceuticals drives a consistent need for this compound.
• Demand in Dye and Pigment Industries: It serves as a key building block for certain dyes and pigments used in textiles and plastics. The continuous need for colored products supports its demand in the sector.
• Speciality Chemical Synthesis: As a fine chemical, N-Acetylsulfanilyl Chloride is valuable for making other specialised organic compounds. This niche demand contributes to its production.
• Regional Production and Consumption:
  • Asia-Pacific (APAC): This region, notably China and India, is both a significant consumer and an emerging producer of chemical intermediates such as N-Acetylsulfanilyl Chloride. The rising demand is fueled by rapid growth in the pharmaceutical, dye, and chemical sectors. Additionally, the cost of establishing a manufacturing plant for N-Acetylsulfanilyl Chloride in this area can be comparatively lower, thanks to readily available feedstock and cost-effective labour.
  • North America and Europe: These are well-established markets with consistent demand for high-purity N-Acetylsulfanilyl Chloride, primarily driven by its use in advanced pharmaceutical synthesis and specialised chemical manufacturing.
     

CAPEX (Capital Expenditure) for an N-Acetylsulfanilyl Chloride Plant

• Site Development and Layout (5-8% of total CAPEX):
  • This includes specific safety zones for highly corrosive and reactive materials.
  • Strong foundations for reactors and storage tanks. Specialised corrosion-resistant drainage and utility hook-ups are vital.
• Raw Material Storage and Handling (10-15%):
  • Acetanilide Storage: Silos or bins for solid acetanilide powder. Includes accurate feeding systems for the reactor.
  • Chlorosulfonic Acid Storage: Specialised, highly corrosion-resistant tanks (e.g., carbon steel with specific linings or glass-lined steel). Safety systems for fuming, corrosive acids are also important. This is a crucial part of the N-Acetylsulfanilyl Chloride manufacturing plant cost.
  • Pumps and Piping: Highly corrosion-resistant and leak-proof pumps and piping for moving chlorosulfonic acid.
• Reaction Section (Chlorosulfonation) (20-25%): 
  • Chlorosulfonation Reactor: Includes a jacketed, agitated reactor. It must be made of highly corrosion-resistant materials (e.g., glass-lined steel or specific alloys). It needs precise temperature control (heating/cooling) to manage the exothermic reaction and ensure high yields.
  • HCl Gas Scrubber: Consists of a robust system to capture and neutralise the hydrogen chloride (HCl) gas released during the reaction. This is essential for safety and environmental compliance.
• Purification Section (25-35%):
  • Quenching/Dilution Systems: Equipment to carefully quench the reaction mixture into ice water, precipitating the crude product.
  • Filtration Units: Plate-and-frame filter presses or centrifuges for separating the solid N-Acetylsulfanilyl Chloride from the acidic aqueous phase. Materials must be acid-resistant.
  • Washing Systems: Tanks and equipment for thorough washing of the filtered product with cold water to remove residual acids.
  • Crystallisation Equipment (Optional for higher purity): If recrystallisation from a solvent (like dry benzene) is used, specialised crystallisers, solvent recovery systems, and filters are required.
  • Drying Equipment: Vacuum dryers or tray dryers to remove residual moisture from the solid product. Drying must be done carefully to prevent decomposition.
• Product Storage and Packaging (5-8%):
  • Finished Product Storage: Moisture-protected storage for solid N-Acetylsulfanilyl Chloride (it can be moisture sensitive).
  • Packaging Lines: Automated packaging machines for bags, drums, or other containers. Packaging must protect the product from moisture.
  • Warehousing: Covered, climate-controlled storage for finished products.
• Utilities and Support Systems (10-15%):
  • Cooling Systems: Large chilling units and cooling towers for quenching the reaction and controlling reactor temperature.
  • Power Supply: Robust electrical infrastructure.
  • Water Treatment: Systems for process water and a robust Effluent Treatment Plant (ETP) for wastewater. Wastewater may be acidic and contain sulfur compounds.
  • Steam Generation: Boilers and pipes for steam (if needed for heating other processes).
  • Compressed Air and Nitrogen: For utilities and inerting.
• Instrumentation and Control Systems (5-8%):
  • Advanced Control Systems: Distributed Control Systems (DCS) or Programmable Logic Controllers (PLCs) for precise temperature, flow, and pressure control. They include extensive safety interlocks for hazardous reactions.
  • Process Analysers: It includes online pH meters, temperature sensors, and laboratory equipment (titration for assay, HPLC for purity) for rigorous quality control.
• Safety and Environmental Systems (5-10%): This is a very significant factor due to corrosive materials and hazardous gas release.
  • Acid Gas Scrubbers: Robust systems for HCl and SOx emissions.
  • Emergency Shutdown (ESD) Systems: Automated systems for rapid plant shutdown in emergencies.
  • Containment for Spills: Specialised bunding and drainage for corrosive liquids.
  • Personal Protective Equipment (PPE) Stations: Extensive safety equipment. These add to the total capital expenditure (CAPEX).
     

OPEX (Operating Expenses) for an N-Acetylsulfanilyl Chloride Plant

• Raw Material Costs (50-65% of total OPEX): This represents the largest manufacturing expense.
  • Acetanilide: Cost per ton.
  • Chlorosulfonic Acid: Cost per ton.
  • Other Chemicals: Water (for quenching, washing), any minor processing aids.
• Energy Costs (15-20%): The process demands energy for heating, cooling, and drying.
  • Electricity: For powering pumps, agitators, refrigeration units, and drying systems.
  • Steam: For heating reactors (if needed for initial heating), and distillation (if solvent recovery is integrated).
  • Cooling Water: For managing exothermic reactions and quenching.
  • Optimising energy use through efficient heat exchange is a constant effort to manage operating expenses (OPEX).
• Labour Costs (8-12%):
  • Salaries, benefits, and training for skilled plant personnel, including operators (who require specialised training to handle corrosive chemicals), chemical engineers, quality control technicians, and maintenance teams, also play an important role.
• Consumables and Spares (3-5%):
  • Replacement parts for corrosion-resistant equipment (glass linings, speciality alloys), pumps, and filters.
  • Filter media for product separation.
  • Lab chemicals for testing.
  • Packaging materials.
• Maintenance and Repairs (3-4%):
  • Regular inspections and preventative maintenance for all equipment, especially corrosion-prone reactors and piping.
  • Addressing unexpected breakdowns promptly.
• Utilities (Non-Energy) (1-2%):
  • Water for process, cooling, and washing. This includes costs for water treatment.
  • Compressed air.
  • Nitrogen gas for inerting.
• Environmental Costs and Waste Disposal (3-5%): This is a significant factor due to acidic emissions and corrosive waste.
  • Costs for running HCl gas scrubbers.
  • Costs for running wastewater treatment plants (ETP) for acidic and organic effluents.
  • Fees for disposing of any chemical waste or off-spec products.
  • Permit fees and monitoring for environmental rules.
• Depreciation and Amortisation: These are non-cash costs that allocate the N-Acetylsulfanilyl Chloride plant capital cost over the operational life of the assets.
• Overhead and Administrative Costs (2-3%):
  • General office costs, insurance (often higher for plants with hazardous chemicals), property taxes, R&D for product improvement, and sales/marketing.
     

Manufacturing Process of N-Acetylsulfanilyl Chloride

The industrial manufacturing report examines the value chain evaluation for N-Acetylsulfanilyl Chloride manufacturing. It also presents a detailed production cost analysis for industrial N-Acetylsulfanilyl Chloride manufacturing. This chemical is produced by reacting acetanilide with chlorosulfonic acid.
 

Production from Acetanilide:

The synthesis of N-Acetylsulfanilyl Chloride starts with acetanilide and chlorosulfonic acid as the starting materials. Acetanilide reacts with an excess of chlorosulfonic acid at high temperatures. This chemical reaction leads to the formation of N-Acetylsulfanilyl Chloride as the final product. The reaction also releases hydrogen chloride (HCl) gas. After the reaction, the crude product is purified by cooling in water to precipitate, followed by filtration, washing, and drying.
 

Properties of N-Acetylsulfanilyl Chloride

• Chemical Formula: C8H8ClNO3S
• Appearance: It is a white to off-white or light grey granular crystalline powder or crystals.
• Odour: It has a pungent, irritating odour, often described as acid-like.
• Melting Point: Around 144-149 degree Celsius (decomposes).
• Solubility: It is slightly soluble in water. However, it is soluble in hot benzene, chloroform, ether, alcohol, and acetonitrile. It reacts with water.
• Reactivity: It is highly reactive due to the sulfonyl chloride group (-SO2Cl). It readily reacts with nucleophiles (e.g., amines, alcohols) to form sulfonamides or sulfonic esters. It also hydrolyses (reacts with water) to form N-acetylsulfanilic acid and hydrochloric acid.
• Stability: It remains stable under normal temperatures and pressures if kept dry. It is moisture-sensitive.
• Corrosivity: It is corrosive due to the release of HCl upon reaction with moisture.
• Hazard: It is a hazardous substance. It is corrosive and can cause severe irritation to the eyes, skin, and respiratory tracts.
   

N-Acetylsulfanilyl Chloride's high reactivity and pivotal role in drug synthesis make it vital for the pharmaceutical industry. Its cash cost of production is shaped by raw material costs and the critical need for strict safety measures due to its corrosive and reactive nature. It's crucial demand in specialised applications ensures its economic feasibility.

N-Acetylsulfanilyl Chloride Manufacturing Plant Report provides you with a detailed assessment of capital investment costs (CAPEX) and operational expenses (OPEX), generally measured as cost per metric ton (USD/MT). This approach ensures that your investment decisions are aligned with the latest industry standards and economic feasibility metrics, enhancing your manufacturing efficiency and financial planning.

Apart from that, this N-Acetylsulfanilyl Chloride manufacturing plant report also covers the leading technology providers that help you plan a robust plan of action related to N-Acetylsulfanilyl Chloride manufacturing plant and its production process, and also by helping you with an in-depth supplier database. This report provides exclusive insights into the best manufacturing practices for N-Acetylsulfanilyl Chloride and technology implementation costs. This report also covers operational cash flow, fixed and variable costs, and detailed break-even point analysis, ensuring that your manufacturing process is not only efficient but also economically viable in the competitive market landscape.

In addition to operational insights, the N-Acetylsulfanilyl Chloride manufacturing plant report also comprehensively focuses on lifecycle cost analysis, maintenance costs, and energy consumption costs, which are critical for maintaining long-term sustainability and profitability. Our manufacturing cost analysis extends to include regulatory compliance costs, inventory holding costs, and logistics and distribution costs, providing a holistic view of the potential expenses and savings.

We at Procurement Resource ensure that this report is not only cost-efficient, environmentally sustainable, and aligned with the latest technological advancements but also that you are equipped with all necessary tools to optimise supply chain operations, manage risks effectively, and achieve superior market positioning for N-Acetylsulfanilyl Chloride.
 

Key Insights and Report Highlights

Key Questions Covered in our N-Acetylsulfanilyl Chloride Manufacturing Plant Report

• How can the cost of producing N-Acetylsulfanilyl Chloride be minimised, cash costs reduced, and manufacturing expenses managed efficiently to maximise overall efficiency?
• What is the estimated N-Acetylsulfanilyl Chloride manufacturing plant cost?
• What are the initial investment and capital expenditure requirements for setting up a N-Acetylsulfanilyl Chloride manufacturing plant, and how do these investments affect economic feasibility and ROI?
• How do we select and integrate technology providers to optimise the production process of N-Acetylsulfanilyl Chloride, and what are the associated implementation costs?
• How can operational cash flow be managed, and what strategies are recommended to balance fixed and variable costs during the operational phase of N-Acetylsulfanilyl Chloride manufacturing?
• How do market price fluctuations impact the profitability and cost per metric ton (USD/MT) for N-Acetylsulfanilyl Chloride, and what pricing strategy adjustments are necessary?
• What are the lifecycle costs and break-even points for N-Acetylsulfanilyl Chloride manufacturing, and which production efficiency metrics are critical for success?
• What strategies are in place to optimise the supply chain and manage inventory, ensuring regulatory compliance and minimising energy consumption costs?
• How can labour efficiency be optimised, and what measures are in place to enhance quality control and minimise material waste?
• What are the logistics and distribution costs, what financial and environmental risks are associated with entering new markets, and how can these be mitigated?
• What are the costs and benefits associated with technology upgrades, modernisation, and protecting intellectual property in N-Acetylsulfanilyl Chloride manufacturing?
• What types of insurance are required, and what are the comprehensive risk mitigation costs for N-Acetylsulfanilyl Chloride manufacturing?